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Regenerative medicine and stem cell therapy for sports injuries (muscle, tendon and ligament injuries)
sports medicine

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Muscle, tendon, and ligament injuries (sports trauma)
Regenerative medicine for early return to work

Our unique
treatment

Why choose our clinic? The secret lies in the strength of our stem cells!
We will explain in detail about our unique culture technology.

[Conversation] Hideo Hashimoto × Dr. Sakamoto
"Effects of Regenerative Medicine and the Right Way to Deal with Injuries"

Click here for more videos
What you can no longer do, you can do again.
What you can no longer do, you can do again.

Sports Medicine Case Studies

See other cases 

The latest in sports medicine is available at
What treatments are available?

For early return to work after sports injuries (muscle, tendon, ligament injuries),
Resuscitation brings hope

Injuries and surgeries can have a profound impact on a sportsman's athletic life. In many cases, athletes return to competition even when they are not fully healed.

In the conventional method, rest for a certain period of time is required for damage to joints, ligaments, muscles, and bones. Basically, it is expected to last from a few weeks to a few months.

However, the current worldwide focus on regenerative medicine is expected to significantly shorten treatment time by promoting repair and regeneration of damaged tissue. This allows sportsmen and women to return to work earlier.

Sports injury, cast on foot

Injuries that normally require surgery may no longer require surgery, eliminating the risk of adverse effects and aftereffects after surgery.

Outside of Japan, many professional sports players and athletes have already received the treatment of Resuscitation Therapy and its success stories are well known. For example, professional baseball player Masao Dota and American Major League Baseball player Shohei Oo⾕ have used regenerative medicine to treat their elbows.

Injuries during Major League Baseball games

Regenerative medicine for sports injuries is
highly
anticipated both nationally and internationally as a state-of-the-art treatment.

With regenerative medicine, I can expect an early return to work and
avoid the risk of surgery sequelae!

In the case of sports injuries, how effective is reanimation therapy for
symptoms?

In our clinic, sprain of the foot joint is relatively common among sports injuries. If treatment for a sprain is inadequate, the risk of recurrence increases. This is because once stretched, the ligaments do not return to their original state.

Conventional therapy usually requires 4 to 8 weeks of immobilization to recover from a sprain, but by using regenerative medicine, the recovery time from injury can be shortened and the patient can be transferred to rehabilitation as soon as possible. This prevents joint contracture and minimizes muscle weakness.

If it's a sports injury, conventional treatment requires a 4- to 8-week immobilization period.
If it's a sports injury, conventional treatment requires a 4- to 8-week immobilization period.

With regenerative medicine, I can get back into sports
faster than with conventional treatment!

You can expect a fast recovery, so
you can minimize both aftereffects and muscle weakness
!

Is
Residential medicine suitable for the treatment of meniscus injuries?

A meniscus injury can be caused by long hours of exercise, such as running a marathon. The pain worsens during practice due to prolonged stress on the knee, and arthroscopic surgery may become necessary as the knee condition deteriorates.

Arthroscopic surgery usually involves removal of the meniscus. The removal of the meniscus increases the risk of wear and tear on the knee cartilage, which can cause new knee pain. This can lead to new knee pain.

Conventional treatment requires arthroscopic surgery to remove the meniscus.
Conventional treatment requires arthroscopic surgery to remove the meniscus.

So arthroscopic surgery could cause new knee pain
...

By using regenerative medicine, it is not necessary to resect the meniscus, and it is expected that the damaged meniscus can be regenerated by injection, which is less stressful on the body.

At the same time, it also protects the joint soft tissue of the knee. This will allow you to continue your marathon running activities for many years to come.

Regenerative therapy requires only a simple injection and no hospitalization.
Regenerative therapy requires only a simple injection and no hospitalization.

With regenerative medicine, there's no need for surgery or hospitalization.
It's a one-day treatment!

So regenerative medicine can leave the meniscus without removing it
and avoid future risks!

Is
reanimation effective for chronic tendon inflammation?

Chronic tendon inflammation, such as golf elbow, tennis elbow, Achilles tendonitis, and tendonitis at foot, can be difficult to treat completely, often with residual pain.

Steroid injections may temporarily relieve symptoms, but their use is limited for a long period of time due to their adverse effects on the tendon. On the other hand, PRP therapy can be used for early pain relief without adversely affecting the tendon itself.

The aim is to return to sports as soon as possible, and the treatment is expected to be effective, which was difficult to achieve in the past. The importance of regenerative medicine will continue to grow.

Regenerative medicine is starting to be used by professional athletes.
Let's take a look together at
what specific conditions are covered!

Regenerative medicine for sports injuries is
indications and diagnoses

Main Symptoms

  • Meniscus injury
  • Knee ligament injury
  • Medial epicondylitis of the elbow (golf elbow)
  • Lateral epicondylitis of the elbow (tennis elbow)
  • Ligamentous wrist injury
  • TFCC injury
  • Plantar tendonitis
  • Rotator cuff tear
  • Patellar tendonitis (jumper's knee)
  • Osgood-Schlatter disease
  • Muscle strain (muscle tear)
  • Achilles tendonitis
  • Ankle ligament injury
  • Tendovaginitis

Those who have already been diagnosed and treated.

  • I want to cure the symptoms that have become chronic.
  • Worried about drug allergies and not being able to treat them.
  • Continued regular steroid treatment.
  • I play sports and would like early treatment.
Dr. Sakamoto, a renowned sports medicine physician

We provide appropriate treatment for pain and symptoms and tailor rehabilitation to each individual patient. We adopt a customized approach to aim for early functional recovery for our patients.

case report

Dr. Sakamoto is also on YouTube! Check out his regenerative medicine channel. Dr. Sakamoto is also on YouTube! Check out his regenerative medicine channel.

Experienced in regenerative medicine / Ranked #1 nationally by age group
Chose regenerative medicine for the culmination of his professional life!

Hideo Hashimoto, former midfielder of Japan's national soccer team, talks about
the benefits of regenerative medicine and his own future [Interview].

If you have a sports injury

Have you heard of regenerative medicine?

Have you heard of regenerative medicine?
Have you heard of regenerative medicine?

The clinic offers
free consultations.

Free Consultation
  • Treatment methods and results
  • Unique stem cell therapy technology
  • Safety and risks
  • Treatment plans and pricing
Chairman Sakamoto
Call for a free consultation 0120-706-313 Toll free/ Office hours: 9:00-18:00
Inquiry / Email Consultation

Characteristics of our regenerative medicine

We aim for the best
treatment for early return to work.

Provide the best treatment and
rehabilitation for early return to work

Initial treatment of ligament injuries, meniscus injuries, soft bone injuries, and muscle tendon injuries is of critical importance. Inadequate treatment may result in residual effects such as pain and instability. Especially for professional athletes, the sequelae of injury can have a serious impact on their athletic life.

We provide state-of-the-art regenerative medicine and the best possible treatment to help injured professional athletes and athletes return to competition and perform at their peak performance as soon as possible. We also provide individualized rehabilitation to aim for early functional recovery.

Injuries during soccer matches

Regeneration by own cells

Stem cells are cells that regenerate into bone, muscle, skin, organs, etc. This versatile property may be used to regenerate damaged parts of the body.

Regenerative medicine stem cells are cells that can become muscle, blood vessels, cranial nerves, bone, and cardiac muscle
Regenerative medicine stem cells are cells that can become muscle, blood vessels, cranial nerves, bone, and cardiac muscle

With regenerative medicine using stem cells,
you can regenerate the damaged area without surgery!

State-of-the-art regenerative medicine is a highly promising and innovative treatment
!

Our Stem Cell Strengths

Characteristics of our hospital (1)

A New Stage in Stem Cell Therapy
Regenerative Medicine Moves into the Era of Differentiation Induction｜Joint Therapy

Regenerative medicine using differentiation induction enables more extensive repair of articular cartilage, meniscus, and osteonecrotic areas.

Delivering what you need where you need it (differentiation induction)
"The Next Generation of Regenerative Medicine"

A New Stage of Stem Cell Therapy
The Next Generation of "Regenerative Medicine " for Joints by Differentiation Induction

In our body, there are "stem cells," that can change into various forms like a fertilized egg.

For example, it can transform itself into nerves, blood vessels, bones, blood, muscles, etc.

This ability to transform is called differentiation..

I see that stem cells can differentiate into various tissues such as nerves, blood vessels, bone, blood, muscle, etc.

Stem cell differentiation
Stem cell differentiation
Stem cell differentiation

The process of guiding stem cells that change into various forms to differentiate into specific tissues such as bones and nerves is called "induction of differentiation.

By inducing differentiation, the administered stem cells can be fully utilized, thereby increasing the regenerative capacity of the targeted tissue.

By inducing stem cells to differentiate into
specific tissues, such as nerve or bone, you can increase the regenerative capacity of the
tissue you want to repair!

Induction of stem cell differentiation
Induction of stem cell differentiation
Induction of stem cell differentiation

Safety and Security

In this differentiation induction process, we do not use any chemical substances or manipulate genes. We use the power of our own cells, so you can receive our treatment with peace of mind.


regenerative medicine for joints by induction of differentiation

The cartilage of the joints has a foundation, which is called the subchondral bone (nankotsukakotsu).

By differentiating and inducing stem cells in this subchondral bone, it is now possible to prepare the foundation and generate a lot of cartilage on top of it, and also to maximize the effect on pain.

In order to regenerate cartilage in the joints, it is important to prepare the "subchondral bone,"
which is the foundation of the cartilage?

Regenerative medicine of joints by induction of differentiation
Regenerative medicine of joints by induction of differentiation

Characteristics of our hospital (2)

The quality of
stem cells is high because they are cultured without freezing.

Since the stem cells are cultured each time they are administered without freezing, they boast a high survival rate.

Our original culture, "as-is" culture
Our original culture, "as-is" culture

It's actually time-consuming to culture them "each time" as they are administered. But we use this method because it increases the survival rate at the time of administration!

Freshly cultured cells are fresh and lively! It is unique to our hospital that cells with high survival and activity rates can be administered every time.

Our original culture, "as-is" culture
Our original culture, "as-is" culture

As the cryopreservation period increases, the cells gradually die, and the surviving cells also lose quality.

Foods also lose their taste and quality when frozen!
It is best to use "freshly prepared" food made "at the time of use" for both cooking and cellular products!

Exactly! I would say that the quality of our unique "on-the-spot" culture is completely different from the general "make-ready" culture.

In Typical Cell Processing Facilities...
Cells are often frozen during storage and transport.

In addition, cryopreserved cells that are made and stored in cell processing rooms are generally transported frozen to other medical facilities.

These cryopreserved cells are transported to medical facilities while frozen, then thawed before use.However, many cells die or weaken during the thawing process, reducing their effectiveness.

General cell processing room General cell processing room

Features of our hospital (iii)

Using the patient's own blood
Safe culture method without blood substitutes

We do not use blood substitutes in cell culture.

I don't use it.
  • Blood substitutes
    (bovine serum, artificial serum)
We do not use blood substitutes in cell culture.

We insist on using only your own cells and
blood!

High safety and survival rates

At our clinic, we culture with your own blood, which is free of impurities and chemicals, ensuring high safety and survival rates. Some facilities use bovine blood or artificial blood called serum-free medium for culture.

High safety and survival rates

Generally, bovine blood and serum-free culture media are used for research purposes, but there are still concerns about allergies and mad cow disease in the clinical setting when actually administered to the human body.

In addition, although culturing stem cells from one's own blood requires advanced culturing techniques, stem cells cultured from one's own blood have strong vitality and can firmly repair damaged areas, enabling treatment with high regenerative potential.

High safety because cells are cultured using the patient's own blood

It is very difficult to culture them using their own blood, but they grow more vibrant cells that way.

I guess using your own cells and blood is more
compatible.

Features of our hospital (4)

Advanced technology for stem cell extraction
Proprietary separation sheets without chemicals or additives

We do not use chemicals or additives in cell culture

I don't use it.
  • Lipolytic enzymes
    (Chemicals)
  •  additive
We do not use any chemicals or additives during cell culture.

No chemicals or additives are used!

High safety and security /
Original culture technology

  • Using our own separation sheet, it is possible to culture stem cells with strong viability.
  • In culture methods using common degradative enzymes (chemicals), cells are weak and survival rates are low. Allergy is also a concern.
High safety and security / Original culture technology

Characteristics of our hospital (5)

High survival and activity rates

Stem cell viability and activity

Understanding stem cell viability and activity rates is very important in understanding regenerative medicine. Even when we talk about stem cell regenerative medicine, there is no uniformity in the way cells are cultured at different medical institutions. This means that the degree to which stem cells are viable and effective also varies from institution to institution.

In other words, the survival and activity rates of stem cells vary from institution to institution, and if the survival and activity rates are low, the desired effect cannot be expected.

Now we will discuss survival and activity rates.

What is Survival Rate?

Viability is the percentage of cultured stem cells that are alive.

Our Stem Cell Culture

Our stem cell culture, high survival rate
Our stem cell culture, high survival rate

General culture

General culture, low survival rate
General culture, low survival rate

What is activity rate?

The activity rate is the percentage of how healthy the living stem cells are.

Our Stem Cell Culture

Our stem cell culture, high activity rate Our stem cell culture, high activity rate

General culture

General culture, low activity rate General culture, low activity rate

Even at the same survival rate, if the living cells are
weaker, the fixation rate will also be lower.

No matter how high the survival rate is, if the living cells are inactive and weak, the stem cells will not be fully effective. In other words, even if the survival rate is high, if there are many weak cells with a low activity rate, the stem cell therapy will be less effective, the stem cell fixation rate will be low, and the therapeutic outcome will be poor.

Features of our hospital (6)

The amount of fat to be extracted is small (about 2-3 grains of rice)
and therefore less stressful to the body

A 1 cm incision is made around the lower abdomen and fat (about 2-3 grains of rice) is harvested. Stem cells are extracted and cultured from the harvested fat cells, and the number of stem cells is increased to 10 to 100 million before they are administered into the body. (The number of cells administered varies depending on whether it is intravenous infusion, intra-articular injection, or intraspinal injection.)

Because stem cells are grown in culture, fewer cells are needed to be harvested, the wound is smaller, and there is almost no pain, so the burden on the body is minimal.

Less burden on the body due to the small amount of cells collected (2-3 grains of rice)
Less burden on the body due to the small amount of cells collected (2-3 grains of rice)

Characteristics of our hospital (7)

Because more than 100 million cells can be administered,
treatment results are good

Since the stem cells are cultured each time they are administered without freezing, they boast a high survival rate.

Comparison of treatment outcomes
(for cartilage regeneration)

General Treatment

  • BEFORE (before stem cell administration) Sakamoto: "The light brown area is bare bone." BEFORE (before stem cell administration) Sakamoto: "The light brown area is bare bone."
  • Stem cell administration: 10 million typical doses Stem cell administration: 10 million typical doses
  • AFTER (6th month of stem cell administration) Cell-kun: "The white area is newly regenerated cartilage!" AFTER (6th month of stem cell administration) Cell-kun: "The white area is newly regenerated cartilage!"

Our Treatment

  • BEFORE (before stem cell administration) Sakamoto: "The light brown area is bare bone." BEFORE (before stem cell administration) Sakamoto: "The light brown area is bare bone."
  • Stem cell administration: 100 million typical doses Stem cell administration: 100 million typical doses
  • AFTER (6th month of stem cell administration) Cell-kun: "The white area is newly regenerated cartilage!" AFTER (6th month of stem cell administration) Cell-kun: "The white area is newly regenerated cartilage!"

Detailed treatment information

Treatment details
Cell therapy using autologous adipose-derived mesenchymal stem cells (intra-articular knee injection).
Since the cells are cultured each time they are administered without freezing, the stem cells have a high survival rate.

Duration and number of treatments

Studies have shown that effects begin to appear 3-6 months after administration.

cost

25 million pieces: 1,320,000 yen (including tax)
50 million pieces: 1,540,000 yen (tax included)
100 million pieces: 1,980,000 yen (tax included)
*This is an unreserved treatment.
A counseling fee of 3,300 yen (including tax) and a blood test fee of 11,000 yen (including tax) are required.
*The price is for a single dose. Discounts will be applied as the number of doses increases.

Major Risks and Side Effects

Pain, swelling, and internal bleeding at the treatment site (generally resolves in a few days)
Infection (extremely rare, but infection may occur during cell culture or administration)
Allergic reactions (extremely rare due to the autologous nature of the cells)
Individual differences in efficacy (efficacy may vary depending on symptoms and age)

The above image was taken from the article " Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. The image above is from the article "Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial.
In this study, the best results were obtained in the high-dose (100 million stem cells) group. Effectiveness may vary from person to person. Please contact our clinic for more information.

Compared to 10 million,
100 million stem cells administered is more
cartilage!

Conclusion. Conclusion. The more stem cells administered, the more
Good treatment results

In the picture, you can clearly see that the more stem cells administered, the more cartilage
is regenerated!

It is common practice to administer about 10 million stem cells in a joint. However, at our clinic, we can administer more than 100 million fresh stem cells that have not been cryopreserved, depending on the patient's symptoms.

It has been proven in clinical data from overseas that the greater the number of stem cells administered, the better the therapeutic outcome.

In addition..!

The quality assurance by a third-party organization makes
safe and secure.

All stem cells confirmed to meet quality standards

All stem cells confirmed to meet quality standards
All stem cells confirmed to meet quality standards

Stem cells cultured under strict control are
evaluated for quality by a third party
to see how they really are!

It's like a certificate of authenticity that proves that the diamond ring is real and of what quality.

Another regenerative medicine
about PRP (Plasma Recycled Platelet) Therapy

                           

PRP therapy is another regenerative medicine that uses the patient's own blood. Our body mobilizes platelets, one of the components of blood, to repair damaged areas. These platelets have the ability to stop bleeding and repair wounds, and PRP therapy uses an extract of platelet-rich components to help relieve pain and inflammation in the knee.

We offer highly concentrated PRP from which platelet components are extracted even more intensively through our unique extraction technology. Compared to general PRP therapy, it is said to be dozens of times more effective, and a quicker response and higher treatment efficacy than usual can be expected. Another feature of this treatment is that the treatment can be performed on the same day the blood is drawn, and the short treatment period is also a major advantage.

Plasma with high platelet counts
Plasma with high platelet counts

PRP Treatment Flow

  • drawing blood

    drawing blood

  • Centrifugation and extraction of plasma components

    Centrifugation and extraction of plasma components

  • Injection into the affected area

    Injection into the affected area

For more information

What exactly is the difference between stem cell therapy and PRP therapy
?

Stem cells can change (differentiate) into new cartilage and regenerate and repair worn cartilage. On the other hand, PRP therapy, like hyaluronic acid and steroid injections, can reduce inflammation in the knee, but unfortunately does not have the ability to regenerate cartilage.

We offer the option of regenerative medicine to those who are not sure whether to go through with surgery. Many of our patients who have undergone adipose-derived stem cell therapy have told us that a simple injection significantly reduces their pain and makes their daily lives easier without surgery.

We hope that this regenerative medicine will become popular among the public as a viable alternative to surgery.

PRP is like making highly effective hyaluronic acid from your own blood.

  • PRP Therapy

    PRP Therapy to the Knee

    PRP containing high levels of platelets is extracted and injected into the knee

    No stem cells, no cartilage.

  • stem cell therapy

    Stem Cell Therapy for Osteoarthritis of the Knee
    Stem Cell Therapy for Osteoarthritis of the Knee

    Stem cells are removed from the body and injected into the
    knee

    Cartilage is produced from stem cells.

Stem Cell Therapy Procedure

At our clinic, stem cell therapy is performed according to the following procedure.

  • Initial consultation and interview (approx. 2 hours)

    01

    Initial consultation and interview (approx. 2 hours)

    The physician will conduct a detailed investigation of the patient's condition and confirm whether stem cell therapy is suitable. After confirmation, the specific treatment process and details are explained, and if consent is obtained, a blood sample is drawn to test for infections and other diseases. After that, we will ask the patient to submit a consent form and start the treatment.

  • Fat collection (about 30 minutes)

    02

    Fat collection (about 30 minutes)

    Local anesthesia is administered to the patient's lower abdomen, and about three grains of fatty tissue are extracted.

  • Cell Culture Process

    03

    Cell Culture Process

    We have submitted a notification to the Ministry of Health, Labor and Welfare and professionally process adipose tissue collected at an accepted cell culture center into the specific cellular products required for treatment.

  • Local administration of specific cellular products (from about 5 min.)

    04

    Administration of specific cellular products

    Local administration (from about 5 min.)

If you have a sports injury

Have you heard of regenerative medicine?

Have you heard of regenerative medicine?
Have you heard of regenerative medicine?

The clinic offers
free consultations.

Free Consultation
  • Treatment methods and results
  • Unique stem cell therapy technology
  • Safety and risks
  • Treatment plans and pricing
Chairman Sakamoto
Call for a free consultation 0120-706-313 Toll free/ Office hours: 9:00-18:00
Inquiry / Email Consultation

The field of regenerative medicine is a new medical field that offers possibilities that were not available in conventional therapies. Stem cell therapy has opened up possibilities for treatments that were previously unattainable, and has advanced to the point where it is now improving the quality of life for many patients.

The Repair Cell Clinic hopes to bring new hope as more and more people benefit from regenerative medicine.

Repair Cell Clinic for Regenerative Medicine TOPtop