Knee joint of a woman in her 70s
Changes evident on x-ray
For knee osteoarthritis sufferers
Regenerative Medicine for Knee Pain
"Non-surgical" Treatment Methods Avoiding Surgery
Our unique
treatment
First in Japan! What is the next generation of regenerative medicine? "Regenerative therapy through differentiation induction (stem cell therapy)" is designed to intensively regenerate damaged tissues.
Osteoarthritis of the knee] Pain makes it hard to sleep and hard to stand...
Stem cell therapy for a very severe condition! What an improvement from immediately after the treatment!
Pleased patient / 60s
Featured Case Reports in Knee Regenerative Medicine
Knee joint of a woman in her 70s
Treatment Details
Regenerative medicine by administration of autologous stem cells
Number of times administered: 3 times
Duration of treatment: Approximately 4 months
Treatment Cost
Treatment cost 100 million stem cells x 3 times administration:
4.29 million yen (tax included)
Major possible risks and side effects
Swelling, pain, internal bleeding, and infection at the site of administration
Progress after treatment
Improvement of joint cavity is confirmed by x-ray
・Reduction of pain after 2 months
Improvement in activities of daily living
This is an example of a case, and the effect of treatment may vary from person to person.
He had severe knee pain and difficulty walking. A nearby hospital recommended an artificial joint, but he decided to undergo regenerative medicine at our hospital because he wanted to avoid surgery.
After the stem cell administration, X-rays clearly showed a larger gap in the medial joint. She was pleased that her knee pain was completely gone and she was able to enjoy traveling and shopping.
I want to avoid surgery! I found regenerative medicine with the desire to avoid surgery!
Why did she choose Repair Cell Clinic? Testimony of a woman in her 70s
Insurance has its limitations.
Common treatments for knee osteoarthritis include injections of hyaluronic acid and steroids, pain medications and compresses, and rehabilitation. Unfortunately, however, these conventional insurance treatments only relieve symptoms and do not prevent cartilage loss, so they are not a fundamental treatment.
Regenerative medicine is "healing without cutting."
The latest alternative to arthroplasty
As osteoarthritis of the knee progresses, walking may become difficult and daily life may become restricted. When this situation occurs, your doctor will often suggest artificial joint surgery.
I used to consider artificial joint surgery, as did other doctors, when conservative treatment did not relieve pain. However, surgery involves risks, and many people are anxious about it.
Even if surgery is successful, postoperative pain and limitation of joint motion often remain indefinitely. In addition, age and health conditions may preclude surgery.
Repair Cell Clinic offers regenerative medicine (stem cell therapy and PRP therapy) as an alternative to conventional treatments and arthroplasty.
Regenerative medicine for the knee:
A new option without artificial joints
With stem cell therapy, simply injecting stem cells into the knee joint regenerates worn cartilage and reduces pain when getting up and walking. In addition, if the deformity is in the early stages, stem cell therapy can prevent the deformity from progressing.
Surgery carries the risk of life-threatening complications such as thrombosis and infection. On the other hand, adipose-derived stem cell therapy is an innovative treatment that can be highly effective without placing a burden on the body.
For this reason, regenerative medicine is attracting attention as a new alternative to artificial joints.
That knee pain, if left untreated, will progress.
Nothing good can come from putting up with knee pain. If the symptoms are left untreated and the knee condition continues to progress, the symptoms of osteoarthritis of the knee will worsen, and the activities of daily living will be severely limited.
If osteoarthritis of the knee is left untreated, the ability to walk will gradually decline, and as a result, muscle strength will also decrease. And as daily life becomes more and more difficult, the likelihood increases that the patient will eventually require physically burdensome treatment such as artificial joint surgery. As the condition progresses further, there is even a risk that the patient may become bedridden or confined to a wheelchair.
Artificial joint surgery is a common treatment option, but if one chooses to undergo surgery, one must also consider the time required for postoperative rehabilitation and functional recovery, which can be physically and mentally demanding. Furthermore, even if you successfully undergo artificial joint surgery, there is a possibility that the pain will not completely disappear. As a matter of fact, we have witnessed many people suffering in the dilemma of having undergone surgery believing that their pain will disappear, but not being able to get rid of it.
In any case, it is important to seek professional medical advice regarding the treatment options that are right for you. If you have knee problems, consider the best treatment options for your body.
The regenerative medicine we offer does not require conventional surgery and does not require hospitalization at all, making it a new treatment option that was previously unthinkable. Questions and consultations regarding treatment are free of charge. Please feel free to contact us.
For those suffering from osteoarthritis of the knee
Have you heard of regenerative medicine?
The clinic offers
free consultations.
- Treatment methods and results
- Unique stem cell therapy technology
- Safety and risks
- Treatment plans and pricing
0120-706-313
Toll free/ Office hours: 09:00-18:00
Regenerative medicine is changing
knee osteoarthritis treatment
People like this one
are indicated for regenerative medicine.
I have hyaluronic acid injections
but they don't last
3 daysI have been advised to have an artificial joint, arthroscopy,
osteotomy, etc.
but I don't want toI can't
take a long vacation to be hospitalized.I don't want to
because of the
risks involved in surgeryI don't want to
prevent the progression of symptoms and
make it serious enough
to have arthroplasty.I was diagnosed with osteonecrosis
Features of our knee regenerative medicine
In comparing regenerative medicine
this is a very important factor!
The higher the number of stem cells, the better the effect.
Generally, about 10 million stem cells are administered, but at our clinic, we administer 25 to 100 million or more stem cells, depending on the condition of the joint.
So the more cells you have, the less pain you have.
Our Stem Cell Strengths
Characteristics of our hospital (1)
A New Stage in Stem Cell Therapy
Regenerative Medicine Moves into the Era of Differentiation Induction｜Joint Therapy
Regenerative medicine using differentiation induction enables more extensive repair of articular cartilage, meniscus, and osteonecrotic areas.
Delivering what you need where you need it (differentiation induction)
"The Next Generation of Regenerative Medicine"
A New Stage of Stem Cell Therapy
The Next Generation of "Regenerative Medicine " for Joints by Differentiation Induction
In our body, there are "stem cells," that can change into various forms like a fertilized egg.
For example, it can transform itself into nerves, blood vessels, bones, blood, muscles, etc.
This ability to transform is called differentiation..
I see that stem cells can differentiate into various tissues such as nerves, blood vessels, bone, blood, muscle, etc.
Stem cell differentiation
The process of guiding stem cells that change into various forms to differentiate into specific tissues such as bones and nerves is called "induction of differentiation.
By inducing differentiation, the administered stem cells can be fully utilized, thereby increasing the regenerative capacity of the targeted tissue.
By inducing stem cells to differentiate into
specific tissues, such as nerve or bone, you can increase the regenerative capacity of the
tissue you want to repair!
Induction of stem cell differentiation
Safety and Security
In this differentiation induction process, we do not use any chemical substances or manipulate genes. We use the power of our own cells, so you can receive our treatment with peace of mind.
regenerative medicine for joints by induction of differentiation
The cartilage of the joints has a foundation, which is called the subchondral bone (nankotsukakotsu).
By differentiating and inducing stem cells in this subchondral bone, it is now possible to prepare the foundation and generate a lot of cartilage on top of it, and also to maximize the effect on pain.
In order to regenerate cartilage in the joints, it is important to prepare the "subchondral bone,"
which is the foundation of the cartilage?
Characteristics of our hospital (2)
The quality of
stem cells is high because they are cultured without freezing.
Since the stem cells are cultured each time they are administered without freezing, they boast a high survival rate.
It's actually time-consuming to culture them "each time" as they are administered. But we use this method because it increases the survival rate at the time of administration!
Freshly cultured cells are fresh and lively! It is unique to our hospital that cells with high survival and activity rates can be administered every time.
As the cryopreservation period increases, the cells gradually die, and the surviving cells also lose quality.
Foods also lose their taste and quality when frozen!
It is best to use "freshly prepared" food made "at the time of use" for both cooking and cellular products!
Exactly! I would say that the quality of our unique "on-the-spot" culture is completely different from the general "make-ready" culture.
In Typical Cell Processing Facilities...
Cells are often frozen during storage and transport.
In addition, cryopreserved cells that are made and stored in cell processing rooms are generally transported frozen to other medical facilities.
These cryopreserved cells are transported to medical facilities while frozen, then thawed before use.However, many cells die or weaken during the thawing process, reducing their effectiveness.
Features of our hospital (iii)
Using the patient's own blood
Safe culture method without blood substitutes
We do not use blood substitutes in cell culture.
I don't use it.
- Blood substitutes
(bovine serum, artificial serum)
We insist on using only your own cells and
blood!
High safety and survival rates
At our clinic, we culture with your own blood, which is free of impurities and chemicals, ensuring high safety and survival rates. Some facilities use bovine blood or artificial blood called serum-free medium for culture.
Generally, bovine blood and serum-free culture media are used for research purposes, but there are still concerns about allergies and mad cow disease in the clinical setting when actually administered to the human body.
In addition, although culturing stem cells from one's own blood requires advanced culturing techniques, stem cells cultured from one's own blood have strong vitality and can firmly repair damaged areas, enabling treatment with high regenerative potential.
It is very difficult to culture them using their own blood, but they grow more vibrant cells that way.
I guess using your own cells and blood is more
compatible.
Features of our hospital (4)
Advanced technology for stem cell extraction
Proprietary separation sheets without chemicals or additives
We do not use chemicals or additives in cell culture
I don't use it.
- Lipolytic enzymes
(Chemicals) - additive
No chemicals or additives are used!
High safety and security /
Original culture technology
- Using our own separation sheet, it is possible to culture stem cells with strong viability.
- In culture methods using common degradative enzymes (chemicals), cells are weak and survival rates are low. Allergy is also a concern.
Characteristics of our hospital (5)
High survival and activity rates
Stem cell viability and activity
Understanding stem cell viability and activity rates is very important in understanding regenerative medicine. Even when we talk about stem cell regenerative medicine, there is no uniformity in the way cells are cultured at different medical institutions. This means that the degree to which stem cells are viable and effective also varies from institution to institution.
In other words, the survival and activity rates of stem cells vary from institution to institution, and if the survival and activity rates are low, the desired effect cannot be expected.
Now we will discuss survival and activity rates.
What is Survival Rate?
Viability is the percentage of cultured stem cells that are alive.
Our Stem Cell Culture
General culture
What is activity rate?
The activity rate is the percentage of how healthy the living stem cells are.
Our Stem Cell Culture
General culture
Even at the same survival rate, if the living cells are
weaker, the fixation rate will also be lower.
No matter how high the survival rate is, if the living cells are inactive and weak, the stem cells will not be fully effective. In other words, even if the survival rate is high, if there are many weak cells with a low activity rate, the stem cell therapy will be less effective, the stem cell fixation rate will be low, and the therapeutic outcome will be poor.
Features of our hospital (6)
The amount of fat to be extracted is small (about 2-3 grains of rice)
and therefore less stressful to the body
A 1 cm incision is made around the lower abdomen and fat (about 2-3 grains of rice) is harvested. Stem cells are extracted and cultured from the harvested fat cells, and the number of stem cells is increased to 10 to 100 million before they are administered into the body. (The number of cells administered varies depending on whether it is intravenous infusion, intra-articular injection, or intraspinal injection.)
Because stem cells are grown in culture, fewer cells are needed to be harvested, the wound is smaller, and there is almost no pain, so the burden on the body is minimal.
Characteristics of our hospital (7)
Because more than 100 million cells can be administered,
treatment results are good
Since the stem cells are cultured each time they are administered without freezing, they boast a high survival rate.
Comparison of treatment outcomes
(for cartilage regeneration)
General Treatment
Our Treatment
Detailed treatment information
Treatment details
Cell therapy using autologous adipose-derived mesenchymal stem cells (intra-articular knee injection).
Since the cells are cultured each time they are administered without freezing, the stem cells have a high survival rate.
Duration and number of treatments
Studies have shown that effects begin to appear 3-6 months after administration.
cost
25 million pieces: 1,320,000 yen (including tax)
50 million pieces: 1,540,000 yen (tax included)
100 million pieces: 1,980,000 yen (tax included)
*This is an unreserved treatment.
A counseling fee of 3,300 yen (including tax) and a blood test fee of 11,000 yen (including tax) are required.
*The price is for a single dose. Discounts will be applied as the number of doses increases.
Major Risks and Side Effects
Pain, swelling, and internal bleeding at the treatment site (generally resolves in a few days)
Infection (extremely rare, but infection may occur during cell culture or administration)
Allergic reactions (extremely rare due to the autologous nature of the cells)
Individual differences in efficacy (efficacy may vary depending on symptoms and age)
The above image was taken from the article " Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. The image above is from the article "Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. In this study, the best results were obtained in the high-dose (100 million stem cells) group. Effectiveness may vary from person to person. Please contact our clinic for more information.
Compared to 10 million,
100 million stem cells administered is more
cartilage!
The more stem cells administered, the more
Good treatment results
In the picture, you can clearly see that the more stem cells administered, the more cartilage
is regenerated!
It is common practice to administer about 10 million stem cells in a joint. However, at our clinic, we can administer more than 100 million fresh stem cells that have not been cryopreserved, depending on the patient's symptoms.
It has been proven in clinical data from overseas that the greater the number of stem cells administered, the better the therapeutic outcome.
In addition..!
The quality assurance by a third-party organization makes
safe and secure.
All stem cells confirmed to meet quality standards
Stem cells cultured under strict control are
evaluated for quality by a third party
to see how they really are!
It's like a certificate of authenticity that proves that the diamond ring is real and of what quality.
Another regenerative medicine
about PRP (Plasma Recycled Platelet) Therapy
PRP therapy is another regenerative medicine that uses the patient's own blood. Our body mobilizes platelets, one of the components of blood, to repair damaged areas. These platelets have the ability to stop bleeding and repair wounds, and PRP therapy uses an extract of platelet-rich components to help relieve pain and inflammation in the knee.
We offer highly concentrated PRP from which platelet components are extracted even more intensively through our unique extraction technology. Compared to general PRP therapy, it is said to be dozens of times more effective, and a quicker response and higher treatment efficacy than usual can be expected. Another feature of this treatment is that the treatment can be performed on the same day the blood is drawn, and the short treatment period is also a major advantage.
PRP Treatment Flow
-
drawing blood
-
Centrifugation and extraction of plasma components
-
Injection into the affected area
What exactly is the difference between stem cell therapy and PRP therapy
?
Stem cells can change (differentiate) into new cartilage and regenerate and repair worn cartilage. On the other hand, PRP therapy, like hyaluronic acid and steroid injections, can reduce inflammation in the knee, but unfortunately does not have the ability to regenerate cartilage.
We offer the option of regenerative medicine to those who are not sure whether to go through with surgery. Many of our patients who have undergone adipose-derived stem cell therapy have told us that a simple injection significantly reduces their pain and makes their daily lives easier without surgery.
We hope that this regenerative medicine will become popular among the public as a viable alternative to surgery.
PRP is like making highly effective hyaluronic acid from your own blood.
-
PRP Therapy
PRP containing high levels of platelets is extracted and injected into the knee
No stem cells, no cartilage.
-
stem cell therapy
Stem cells are removed from the body and injected into the
kneeCartilage is produced from stem cells.
What will happen?
What happens when you have osteoarthritis of the knee
?
ひざへの負担がかかり徐々にひざの軟骨がすり減ることで炎症が起こり、ひざの痛みで歩いたり、階段の上り下りが辛くなります。症状としては水が溜まったり、ひざの曲げ伸ばしができにくくなり正座もできなくなったりします。病気が進行してひどくなると、大きく関節が変形してO脚やX脚が顕著になり、ひざもほとんど曲がらなくなり歩くことすら出来なくなります。
Difficulty walking can lead to inactivity, loss of strength, and in the worst case, bedridden. And once cartilage is worn away and gone, it cannot return to normal on its own.
-
initial
- Knee pain when starting to walk or standing up
- Pain begins after prolonged walking, but subsides after rest.
-
advanced stage
- Sitting on the floor or sitting at a table is difficult
- Going up and down stairs is hard.
- water in the knees
-
terminal (e.g. cancer, disease, etc.)
- Intense pain makes it difficult to even walk.
- O- or X-leg deformity and loss of leg extension.
Stem Cell Therapy Procedure
At our clinic, stem cell therapy is performed according to the following procedure.
-
01
Initial consultation and interview (approx. 2 hours)
The physician will conduct a detailed investigation of the patient's condition and confirm whether stem cell therapy is suitable. After confirmation, the specific treatment process and details are explained, and if consent is obtained, a blood sample is drawn to test for infections and other diseases. After that, we will ask the patient to submit a consent form and start the treatment.
-
02
Fat collection (about 30 minutes)
Local anesthesia is administered to the patient's lower abdomen, and about three grains of fatty tissue are extracted.
-
03
Cell Culture Process
We have submitted a notification to the Ministry of Health, Labor and Welfare and professionally process adipose tissue collected at an accepted cell culture center into the specific cellular products required for treatment.
-
04
Administration of specific cellular products
Local administration (from about 5 min.)
For knee pain and osteoarthritis
regenerative medicine
Have you heard of regenerative medicine?
The clinic offers
free consultations.
- Treatment methods and results
- Unique stem cell therapy technology
- Safety and risks
- Treatment plans and pricing
0120-706-313
Toll free/ Office hours: 09:00-18:00
Osteoarthritis of the knee is a disease that affects approximately
30 million people nationwide.
The following pages detail the causes, early symptoms,
treatment options, and more.
Medical institutions notified by the Ministry of Health, Labor and Welfare
Type II and Type III regenerative medicine, etc.
Plan of provision Notified
Repair Cell Clinic has submitted a Type 2 and Type 3 Regenerative Medicine Provision Plan to the Ministry of Health, Labour and Welfare, which has been accepted.
Using autologous adipose-derived stem cells to treat
osteoarthritis
Treatment of Osteoarthritis with Polyplatelet Plasma (PRP)
Our clinic provides cutting-edge regenerative medicine using autologous stem cells, one of the few in Japan, for "osteoarthritis," "stroke," "diabetes," "liver disorders," and "skin regeneration," as well as intra-articular administration of PRP (platelet-rich plasma) under the Regenerative Medicine Safety Assurance Act, as a free medical service. Regenerative medicine is subject to strict review by the Ministry of Health, Labour and Welfare (MHLW), and a treatment plan can be submitted to the MHLW only when the appropriateness, safety, and physician system of the treatment are deemed appropriate.
In my many years of outpatient insurance practice, I have seen many cases of osteoarthritis of the knee that progressed over several years with conventional treatment, with a marked loss of cartilage that was clearly visible on X-ray images.