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Regenerative Medicine for Spinal Cord Injury
(Adipose-derived mesenchymal stem cell therapy) SPINAL CORD INJURY

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    (Adipose-derived mesenchymal stem cell therapy)

Spinal Cord Injury Sequelae / Cutting Edge! Stem Cell Therapy Not a conventional intravenous therapy
Direct Intra-Spinal Cavity Injection Therapy

Our unique
treatment

Spinal Cord Injury] How could I get so much better 8 years after the injury?
Hear the joy after regenerative medicine (stem cell therapy)!

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What you can no longer do, you can do again.
What you can no longer do, you can do again.

Featured Case Reports

Stem cell therapy has produced amazing results for many patients. They have reported a variety of positive results, including improved limb movement, language function, and quality of life.

gender masculine gender
age 70代
disease name cervical spondylotic myelopathy
symptoms
  • Numbness and muscle weakness in limbs
  • Lack of strength in limbs
  • Staggering when walking
  • Frequently falls over.
Treatment Intraspinal injection 25 million cells 3 times
                                   

Stem cell administration results

  • Improved muscle strength Improved numbness
  • Better balance.
  • Walking became more stable Walking speed increased
  • Normalized hand movements.
  • Easier to bend and stretch arms.

Spinal Cord Injury Case Studies

See other cases 


state-of-the-art treatment for spinal cord injury sequelae

The spinal cord is part of the central nervous system, and some of the nerves leaving the brain send signals through the spinal cord to various parts of the body to control movement and sensation. Spinal cord injuries cause significant impairment to the function of the spinal cord.

Spinal cord injuries can result in permanent paralysis and loss of sensation, which can have a significant impact on daily life. Until now, treatment has included surgery, rehabilitation, and drug therapy, but in recent years, research has advanced and regenerative medicine using stem cells is now being used around the world.

Stem cell therapy is a treatment that aims to repair damaged tissues using stem cells that have the ability to self-regenerate. Stem cell therapy is also expected to regenerate and repair nerve tissue forthe aftereffects of spinal cord injury.

State-of-the-art treatment for the aftereffects of spinal cord injury

What is
effective treatment for the sequelae of spinal cord injury?

Until now, there has been no effective treatment for spinal cord injury, and as a result, many people have been forced to live in wheelchairs or are bedridden due to the aftereffects of spinal cord injury. However, with the recent progress in research, many cases of recovery from the aftereffects of spinal cord injury have been reported by receiving regenerative medicine using stem cells.

Medical Specialist: Dr. Sakamoto

There are only a few medical institutions in Japan that offer stem cell therapy for spinal cord injury, and most of them use intravenous infusion.
At our clinic, in addition to intravenous infusion, patients can also choose "direct injection into the spinal cord cavity," which is a treatment that more easily approaches nerve regeneration.
We have had many patients visit our clinic and experience the benefits of this treatment, which is a testament to its effectiveness.

Thinking Sakamoto-kun

What will happen?

What happens when you have a spinal cord injury?

The spinal cord is a bundle of nerves that connects the brain to the body and transmits movement and sensation. The spinal cord runs through the spine. If the spinal cord is subjected to strong external force due to a car accident, fall from a height, or trauma, the nerves may be damaged, resulting in motor paralysis of the hands and feet, paresthesia, autonomic dysfunction, urinary and defecation dysfunction, and so on.

Depending on the extent of the damage, there are two types of paralysis: complete paralysis, in which the patient is completely unable to move or feel, and incomplete paralysis, in which some functionality remains.

Examples of Spinal Cord Injury Symptoms

For those suffering from the aftereffects of a spinal cord injury

Do you have any of the following problems?

  • Numbness and paralysis

    Numbness and paralysis
    • have numbness in one's hands and feet
    • Feeling in one's hands and feet is weak.
    • I have trouble moving my arms and legs.
    • Knots in my body ache.

  • Restrictions on daily life

    Restrictions on daily life
    • Walking speed is slow
    • Balance is poor and needs a cane
    • Stumble often
    • be on the verge of a fall
    • Inability to hold back urination and defecation

  • Other concerns

    Other concerns
    • Suffering from aftereffects after surgery
    • I don't feel
      effective after rehab.

If you would like to hear more about our treatment, please contact us at
for a free consultation.

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Our Strengths in Regenerative Medicine - Direct Intracavitary Spinal Cavity Injection Therapy -.

The key is direct into the spinal cord cavity!
Stem cells are more effective at regenerating and repairing nerves when they're administered directly into the spinal cord cavity.

Direct administration of stem cells to the damaged area
"Our unique intraspinal direct injection therapy!

With an IV, the numbers are down by the time
reaches the wrong part of the spinal cord.

The most common method of regenerative medicine for spinal cord injury is to administer stem cells intravenously and allow them to reach the spinal cord through the blood circulation. However, this method tends to limit the quantity of stem cells that can reach the injured spinal cord because stem cells injected into blood vessels are distributed throughout the body.

IV infusion reduces the number of stem cells reaching the trunk. IV infusion reduces the number of stem cells reaching the trunk.
Dr. Sakamoto, regenerative medicine specialist, our treatment is effective because it delivers stem cells directly to the affected area.
Dr. Sakamoto, regenerative medicine specialist, our treatment is effective because it delivers stem cells directly to the affected area.

We offer a new treatment that has rarely been reported in Japan: the direct administration of stem cells to the damaged nerve site of the spinal cord. This treatment method directly administers stem cells to the damaged area of the spinal cord and is expected to repair and regenerate nerves near the spinal cord better than intravenous administration, which is effective throughout the body.

Intraspinal Direct Injection Therapy

Stem cell therapy administered directly into the spinal cord cavity
Stem cell therapy administered directly into the spinal cord cavity
STEP 1
It is administered by injection with a fine needle into the subarachnoid space (spinal cavity).
STEP2
After administration, stem cells flow into the spinal fluid.
STEP 3
Spinal fluid flows through the spinal cord and can deliver stem cells to the site of spinal cord injury.

The treatment is a simple injection that takes only a few minutes and is not very painful. Further effects can be expected when combined with stem cell infusion.

Because it's injected directly into the damaged area of the spinal cord,
it's more effective at regenerating and repairing the spinal nerves
!

Strengths of our stem cell therapy

There are two main methods of regenerative medicine for spinal cord injury: bone marrow-derived stem cells from the pelvis and
adipose-derived stem cells.

Why does the Repair Cell Clinic administer
adipose-derived stem cells instead of
bone marrow-derived?

Differences between adipose-derived stem cells and bone marrow-derived stem cells

Regenerative medicine at our clinic uses stem cells in fat rather than stem cells taken from bone marrow. Bone marrow stem cells are said to differentiate easily into nerve cells, but they have the disadvantage of being difficult to proliferate.

On the other hand, fat stem cells are more proliferative and can differentiate into blood vessels and various other tissues that assist nerve cells, in addition to nerve cells, making them more effective overall than bone marrow stem cells.

Recent studies have shown that stem cells from fat have better outcomes than stem cells from bone marrow. Our clinic is one of the few medical institutions in Japan that were the first to introduce this cutting-edge therapy, stem cell therapy from fat.

Differences between adipose-derived stem cells and bone marrow-derived stem cells

The more stem cells you have, the more effective you are.
Is that true?

The more stem cells administered, the better the therapeutic outcome, as proven by clinical data from overseas.

It's also a very safe thing to do!

Adipose-derived
Intraspinal
Direct
Injection		 Adipose-derived
stem cell infusion		 Bone marrow derived
stem cell infusion
Expectations
Can
Effect		 ◎ (To be administered
into the spinal cavity)		 period weak
growth rate high high low (position)
cell potency Can differentiate into
many tissues, including tissues that help
blood vessels and nerve cells		 Can differentiate into
many tissues, including tissues that help
blood vessels and nerve cells		 Neurons have
easy differentiation
Treatment
pain		 Almost
No pain		 Almost
No pain		 Pain associated with bone marrow puncture.
hospitalization not required not required not required

Use of adipose-derived stem cells

  • Highly safe to collect
  • Less stressful to the body than bone marrow, synovial or visceral stem cells
Use of autologous stem cells

Another reason is that bone marrow puncture (marc), which involves harvesting stem cells from the bone marrow, carries a high risk of infection.

If you have a spinal cord injury and need help with

Have you heard of regenerative medicine?

Have you heard of regenerative medicine?
Have you heard of regenerative medicine?

The clinic offers
free consultations.

Free Consultation
  • Treatment methods and results
  • Unique stem cell therapy technology
  • Safety and risks
  • Treatment plans and pricing
Chairman Sakamoto
Call for a free consultation 0120-706-313 Toll free/ Office hours: 09:00-18:00
Inquiry / Email Consultation

Our Stem Cell Strengths

Characteristics of our hospital (1)

A New Stage in Stem Cell Therapy
Regenerative Medicine Moves into the Era of Differentiation Induction｜Joint Therapy

Regenerative medicine using differentiation induction enables more extensive repair of articular cartilage, meniscus, and osteonecrotic areas.

Delivering what you need where you need it (differentiation induction)
"The Next Generation of Regenerative Medicine"

A New Stage of Stem Cell Therapy
The Next Generation of "Regenerative Medicine " for Joints by Differentiation Induction

In our body, there are "stem cells," that can change into various forms like a fertilized egg.

For example, it can transform itself into nerves, blood vessels, bones, blood, muscles, etc.

This ability to transform is called differentiation..

I see that stem cells can differentiate into various tissues such as nerves, blood vessels, bone, blood, muscle, etc.

Stem cell differentiation
Stem cell differentiation
Stem cell differentiation

The process of guiding stem cells that change into various forms to differentiate into specific tissues such as bones and nerves is called "induction of differentiation.

By inducing differentiation, the administered stem cells can be fully utilized, thereby increasing the regenerative capacity of the targeted tissue.

By inducing stem cells to differentiate into
specific tissues, such as nerve or bone, you can increase the regenerative capacity of the
tissue you want to repair!

Induction of stem cell differentiation
Induction of stem cell differentiation
Induction of stem cell differentiation

Safety and Security

In this differentiation induction process, we do not use any chemical substances or manipulate genes. We use the power of our own cells, so you can receive our treatment with peace of mind.


regenerative medicine for joints by induction of differentiation

The cartilage of the joints has a foundation, which is called the subchondral bone (nankotsukakotsu).

By differentiating and inducing stem cells in this subchondral bone, it is now possible to prepare the foundation and generate a lot of cartilage on top of it, and also to maximize the effect on pain.

In order to regenerate cartilage in the joints, it is important to prepare the "subchondral bone,"
which is the foundation of the cartilage?

Regenerative medicine of joints by induction of differentiation
Regenerative medicine of joints by induction of differentiation

Characteristics of our hospital (2)

The quality of
stem cells is high because they are cultured without freezing.

Since the stem cells are cultured each time they are administered without freezing, they boast a high survival rate.

Our original culture, "as-is" culture
Our original culture, "as-is" culture

It's actually time-consuming to culture them "each time" as they are administered. But we use this method because it increases the survival rate at the time of administration!

Freshly cultured cells are fresh and lively! It is unique to our hospital that cells with high survival and activity rates can be administered every time.

Our original culture, "as-is" culture
Our original culture, "as-is" culture

As the cryopreservation period increases, the cells gradually die, and the surviving cells also lose quality.

Foods also lose their taste and quality when frozen!
It is best to use "freshly prepared" food made "at the time of use" for both cooking and cellular products!

Exactly! I would say that the quality of our unique "on-the-spot" culture is completely different from the general "make-ready" culture.

In Typical Cell Processing Facilities...
Cells are often frozen during storage and transport.

In addition, cryopreserved cells that are made and stored in cell processing rooms are generally transported frozen to other medical facilities.

These cryopreserved cells are transported to medical facilities while frozen, then thawed before use.However, many cells die or weaken during the thawing process, reducing their effectiveness.

General cell processing room General cell processing room

Features of our hospital (iii)

Using the patient's own blood
Safe culture method without blood substitutes

We do not use blood substitutes in cell culture.

I don't use it.
  • Blood substitutes
    (bovine serum, artificial serum)
We do not use blood substitutes in cell culture.

We insist on using only your own cells and
blood!

High safety and survival rates

At our clinic, we culture with your own blood, which is free of impurities and chemicals, ensuring high safety and survival rates. Some facilities use bovine blood or artificial blood called serum-free medium for culture.

High safety and survival rates

Generally, bovine blood and serum-free culture media are used for research purposes, but there are still concerns about allergies and mad cow disease in the clinical setting when actually administered to the human body.

In addition, although culturing stem cells from one's own blood requires advanced culturing techniques, stem cells cultured from one's own blood have strong vitality and can firmly repair damaged areas, enabling treatment with high regenerative potential.

High safety because cells are cultured using the patient's own blood

It is very difficult to culture them using their own blood, but they grow more vibrant cells that way.

I guess using your own cells and blood is more
compatible.

Features of our hospital (4)

Advanced technology for stem cell extraction
Proprietary separation sheets without chemicals or additives

We do not use chemicals or additives in cell culture

I don't use it.
  • Lipolytic enzymes
    (Chemicals)
  •  additive
We do not use any chemicals or additives during cell culture.

No chemicals or additives are used!

High safety and security /
Original culture technology

  • Using our own separation sheet, it is possible to culture stem cells with strong viability.
  • In culture methods using common degradative enzymes (chemicals), cells are weak and survival rates are low. Allergy is also a concern.
High safety and security / Original culture technology

Characteristics of our hospital (5)

High survival and activity rates

Stem cell viability and activity

Understanding stem cell viability and activity rates is very important in understanding regenerative medicine. Even when we talk about stem cell regenerative medicine, there is no uniformity in the way cells are cultured at different medical institutions. This means that the degree to which stem cells are viable and effective also varies from institution to institution.

In other words, the survival and activity rates of stem cells vary from institution to institution, and if the survival and activity rates are low, the desired effect cannot be expected.

Now we will discuss survival and activity rates.

What is Survival Rate?

Viability is the percentage of cultured stem cells that are alive.

Our Stem Cell Culture

Our stem cell culture, high survival rate
Our stem cell culture, high survival rate

General culture

General culture, low survival rate
General culture, low survival rate

What is activity rate?

The activity rate is the percentage of how healthy the living stem cells are.

Our Stem Cell Culture

Our stem cell culture, high activity rate Our stem cell culture, high activity rate

General culture

General culture, low activity rate General culture, low activity rate

Even at the same survival rate, if the living cells are
weaker, the fixation rate will also be lower.

No matter how high the survival rate is, if the living cells are inactive and weak, the stem cells will not be fully effective. In other words, even if the survival rate is high, if there are many weak cells with a low activity rate, the stem cell therapy will be less effective, the stem cell fixation rate will be low, and the therapeutic outcome will be poor.

Features of our hospital (6)

The amount of fat to be extracted is small (about 2-3 grains of rice)
and therefore less stressful to the body

A 1 cm incision is made around the lower abdomen and fat (about 2-3 grains of rice) is harvested. Stem cells are extracted and cultured from the harvested fat cells, and the number of stem cells is increased to 10 to 100 million before they are administered into the body. (The number of cells administered varies depending on whether it is intravenous infusion, intra-articular injection, or intraspinal injection.)

Because stem cells are grown in culture, fewer cells are needed to be harvested, the wound is smaller, and there is almost no pain, so the burden on the body is minimal.

Less burden on the body due to the small amount of cells collected (2-3 grains of rice)
Less burden on the body due to the small amount of cells collected (2-3 grains of rice)

Characteristics of our hospital (7)

Because more than 100 million cells can be administered,
treatment results are good

Since the stem cells are cultured each time they are administered without freezing, they boast a high survival rate.

Comparison of treatment outcomes
(for cartilage regeneration)

General Treatment

  • BEFORE (before stem cell administration) Sakamoto: "The light brown area is bare bone." BEFORE (before stem cell administration) Sakamoto: "The light brown area is bare bone."
  • Stem cell administration: 10 million typical doses Stem cell administration: 10 million typical doses
  • AFTER (6th month of stem cell administration) Cell-kun: "The white area is newly regenerated cartilage!" AFTER (6th month of stem cell administration) Cell-kun: "The white area is newly regenerated cartilage!"

Our Treatment

  • BEFORE (before stem cell administration) Sakamoto: "The light brown area is bare bone." BEFORE (before stem cell administration) Sakamoto: "The light brown area is bare bone."
  • Stem cell administration: 100 million typical doses Stem cell administration: 100 million typical doses
  • AFTER (6th month of stem cell administration) Cell-kun: "The white area is newly regenerated cartilage!" AFTER (6th month of stem cell administration) Cell-kun: "The white area is newly regenerated cartilage!"

Detailed treatment information

Treatment details
Cell therapy using autologous adipose-derived mesenchymal stem cells (intra-articular knee injection).
Since the cells are cultured each time they are administered without freezing, the stem cells have a high survival rate.

Duration and number of treatments

Studies have shown that effects begin to appear 3-6 months after administration.

cost

25 million pieces: 1,320,000 yen (including tax)
50 million pieces: 1,540,000 yen (tax included)
100 million pieces: 1,980,000 yen (tax included)
*This is an unreserved treatment.
A counseling fee of 3,300 yen (including tax) and a blood test fee of 11,000 yen (including tax) are required.
*The price is for a single dose. Discounts will be applied as the number of doses increases.

Major Risks and Side Effects

Pain, swelling, and internal bleeding at the treatment site (generally resolves in a few days)
Infection (extremely rare, but infection may occur during cell culture or administration)
Allergic reactions (extremely rare due to the autologous nature of the cells)
Individual differences in efficacy (efficacy may vary depending on symptoms and age)

The above image was taken from the article " Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. The image above is from the article "Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial.
In this study, the best results were obtained in the high-dose (100 million stem cells) group. Effectiveness may vary from person to person. Please contact our clinic for more information.

Compared to 10 million,
100 million stem cells administered is more
cartilage!

Conclusion. Conclusion. The more stem cells administered, the more
Good treatment results

In the picture, you can clearly see that the more stem cells administered, the more cartilage
is regenerated!

It is common practice to administer about 10 million stem cells in a joint. However, at our clinic, we can administer more than 100 million fresh stem cells that have not been cryopreserved, depending on the patient's symptoms.

It has been proven in clinical data from overseas that the greater the number of stem cells administered, the better the therapeutic outcome.

In addition..!

The quality assurance by a third-party organization makes
safe and secure.

All stem cells confirmed to meet quality standards

All stem cells confirmed to meet quality standards
All stem cells confirmed to meet quality standards

Stem cells cultured under strict control are
evaluated for quality by a third party
to see how they really are!

It's like a certificate of authenticity that proves that the diamond ring is real and of what quality.

Stem Cell Therapy Procedure

At our clinic, stem cell therapy is performed according to the following procedure.

  • Initial consultation and interview (approx. 2 hours)

    01

    Initial consultation and interview (approx. 2 hours)

    The physician will conduct a detailed investigation of the patient's condition and confirm whether stem cell therapy is suitable. After confirmation, the specific treatment process and details are explained, and if consent is obtained, a blood sample is drawn to test for infections and other diseases. After that, we will ask the patient to submit a consent form and start the treatment.

  • Fat collection (about 30 minutes)

    02

    Fat collection (about 30 minutes)

    Local anesthesia is administered to the patient's lower abdomen, and about three grains of fatty tissue are extracted.

  • Cell Culture Process

    03

    Cell Culture Process

    We have submitted a notification to the Ministry of Health, Labor and Welfare and professionally process adipose tissue collected at an accepted cell culture center into the specific cellular products required for treatment.

  • Intravenous infusion of specific cellular products

    04


    intravenous infusion of specific cellular products

    -I.V. administration (approx. 80 min)
    -Local injection (from approx. 5 min)

If you have a spinal cord injury and need help with

Have you heard of regenerative medicine?

Have you heard of regenerative medicine?
Have you heard of regenerative medicine?

The clinic offers
free consultations.

Free Consultation
  • Treatment methods and results
  • Unique stem cell therapy technology
  • Safety and risks
  • Treatment plans and pricing
Chairman Sakamoto
Call for a free consultation 0120-706-313 Toll free/ Office hours: 09:00-18:00
Inquiry / Email Consultation

Overview and Causes

Falls from heights Traffic accidents Falls due to skiing and snowboarding Sports injuries Osteoporosis, etc.

In Japan, there are more than 100,000 patients with approximately 5,000 new cases each year. These cases are mainly caused by damage to the spinal nerves in the spine due to strong external forces applied to the spine, such as a fall from a height, a sudden accident, a fall caused by skiing or snowboarding, or a sports injury. In recent years, "non-fracture cervical spinal cord injury," which is more common in the elderly, has also been on the rise. This type of spinal cord nerve injury occurs due to osteoporosis or other causes, even when no significant external force is applied. In this type, symptoms such as paralysis of the upper limbs and loss of hand movement are observed mainly.

symptoms

  •  I can't move my body.
  •  Sensation dulls or disappears
  •  I can't breathe.
  •  Urinary and defecation problems occur.

The location and symptoms of paralysis vary depending on the site of spinal cord injury. Spinal cord injuries are generally classified into two categories: complete paralysis and incomplete paralysis. In the case of complete paralysis, there is no muscle movement at all and complete loss of sensation. In the case of incomplete paralysis, some motor function and sensation remain. If the upper cervical spinal cord is damaged, spontaneous respiration is no longer possible and a ventilator may be necessary for survival. Other symptoms may include problems related to urination and defecation.

There are many symptoms of spinal cord injury.

respiratory symptoms

Injury higher than the fourth medulla oblongata limits diaphragmatic movement and makes spontaneous breathing difficult. In this situation, a ventilator is necessary. Injuries lower than the fourth medulla oblongata also limit rib movement, making it difficult to expel phlegm and decreasing lung capacity, increasing the risk of atelectasis and pneumonia.

Cardiovascular Symptoms

Hypotension and bradycardia may occur during orthostasis. From motor paralysis of the lower extremities, there is also an increased risk of economy class syndrome and deep vein thrombosis.

digestive symptoms

Spinal cord injury may result in decreased gastrointestinal motility, resulting in gastric ulcers and paralytic ileus.

urinary symptoms

Urinary and bowel functions are impaired, increasing the risk of urinary tract infections. Diapers may also be required.

complications (in an illness)

Motor paralysis of the limbs makes it difficult to reposition the patient, which can cause pressure sores on the skin and blood circulation problems that can lead to bedsores. Prolonged wheelchair use can also lead to pressure sores on the sacrum.

examination

Diagnosis is made by x-ray, CT, MRI, and other tests.

treatment

If there is spinal cord compression due to fracture or dislocation of the spine, emergency surgery is the treatment of choice.

We offer adipose-derived stem cell therapy to patients suffering from the aftereffects of spinal cord injury. Patients suffering from symptoms such as numbness and paralysis are interested in our regenerative medicine and visit our clinic.

This treatment has reduced numbness and paralysis, and we have received joyful comments that "daily life has become much easier. We hope that this regenerative medicine will continue to spread as a treatment for the aftereffects of spinal cord injury and benefit many patients in the future.

Medical institutions notified by the Ministry of Health, Labor and Welfare

Type II and Type III regenerative medicine, etc.
Plan of provision Notified

Repair Cell Clinic has submitted a Type 2 and Type 3 Regenerative Medicine Provision Plan to the Ministry of Health, Labour and Welfare, which has been accepted.

  • Ministry of Health, Labour and Welfare, Ordinance for Enforcement of the Act on Safety Assurance of Regenerative Medicine, etc., Notification Document "Treatment of Spinal Cord Injury Using Autologous Fat-derived Stem Cells".
  • Ministry of Health, Labour and Welfare, Ordinance for Enforcement of the Act on Safety Assurance of Regenerative Medicine, etc., Notification Document "Treatment of Spinal Cord Injury Using Autologous Fat-derived Stem Cells".

Using autologous adipose-derived stem cells to treat
spinal cord injury

Our clinic provides cutting-edge regenerative medicine using autologous stem cells, one of the few in Japan, for "osteoarthritis," "stroke," "diabetes," "liver disorders," and "skin regeneration," as well as intra-articular administration of PRP (platelet-rich plasma) under the Regenerative Medicine Safety Assurance Act, as a free medical service. Regenerative medicine is subject to strict review by the Ministry of Health, Labour and Welfare (MHLW), and a treatment plan can be submitted to the MHLW only when the appropriateness, safety, and physician system of the treatment are deemed appropriate.

Repair Cell Clinic for Regenerative Medicine TOPtop